Symbol
Name
ID

Rbpj
recombination signal binding protein for immunoglobulin kappa J region
MGI:96522

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Gastrointestinal hemorrhage	Leukopenia	Portal vein thrombosis	Thrombocytopenia	Splenomegaly	Hypersplenism
Disease(s) Associated with RBPJ
Adams-Oliver syndrome

Mouse Phenotypes

increased T cell proliferation

small thymus

decreased thymocyte number

abnormal lymphopoiesis

abnormal B cell differentiation

abnormal T-helper 2 cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

arrested T cell differentiation

increased plasmacytoid dendritic cell number

decreased dendritic cell number

decreased marginal zone B cell number

increased follicular B cell number

increased B cell number

decreased single-positive T cell number

increased T cell number

increased single-positive T cell number

increased macrophage cell number

increased monocyte cell number

abnormal CD4-positive helper T cell morphology

increased splenocyte number

increased IgG3 level

abnormal regulatory T cell physiology

Availability

Mouse Genotype

Cd19^tm1(cre)Cgn/Cd19⁺
Rbpj^tm1Hon/Rbpj^tm1Hon (conditional)

Rbpj^tm1Hon/Rbpj^tm1Hon
Tg(Mx1-cre)1Cgn/0 (conditional)

Rbpj^tm1Hon/Rbpj^tm1Hon
Tg(Itgax-cre)1-1Reiz/0 (conditional)

Rbpj^tm1Hon/Rbpj^tm1Hon
Tg(Cd4-cre)1Cwi/? (conditional)

Rbpj^tm1Hon/Rbpj^tm1Hon
Tg(Lck-cre)19Hhan/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23